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Faculty Scholarship

Department of Biophamaceutical Sciences

Below is a list of scholarship activities reported by the Biopharmaceutical Sciences faculty. Click HERE for access to their contact information.

 

Amusa S. Adebayo, PhD
Biopharmaceutics, Pharmacokinetics & Pharmacometrics

 

Research Specialization Summary

 Formulation material science, dosage form design, development & evaluation; stability and drug biodisposition kinetics, modeling and simulations

Formulation material science, dosage form design, development & evaluation; stability and drug biodisposition kinetics, modeling and simulations

 Scholarship (2010 -)

        (a)          All abstracts submitted/accepted or presented

  1. Amusa S. Adebayo & Jacqueline Wilson, Need survey of post-qualification education requirements of Caribbean Pharmacists, AACP Annual Meeting, Pharmacy Education 2013 Chicago, IL.
  2. Amusa Adebayo, Fred Esseku, Anjali Joshi, Ravikiran Panakanti, Ruth Adewuya, Moji Adeyeye, Age appropriate pharmacokinetic prediction for fixed-dose combination (FDC) of lamivudine, nevirapine and zidovudine using data obtained in a phase 1 clinical trial, 2012 AAPS Annual Meeting and Exposition, October 14 – 18, McCormick Place, Chicago, IL.
  3. Amusa Adebayo, Uday Kotreka, Ravikiran Panakanti, Ruth Adewuya, Moji Adeyeye, Simulated Ocular Bioavailability of Estradiol Based on Preclinical Data in Rabbits, 2012 AAPS Annual Meeting and Exposition, October 14 – 18, McCormick Place, Chicago, IL, October 15, 2012.
  4. Jankie Satish,  Adebayo S. Amusa, Pillai Gopalakrishna, In Vitro Activities of Floroquinolones Entrapped in Non-ionic Surfactant Vesicles Against Multi-drug Resistant Bacteria Strains, Centennial Conference of the International Pharmaceutical Federation (FIP), Amsterdam, The Netherlands, October 3 – 8, 2012.
  5. Noel McFarlane, Amusa S. Adebayo and Eugenie Brown-Myrie, Design and Evaluation of Amlodipine Besylate-Hydrochlorothiazide Immediate-release combination tablets Centennial Conference of the International Pharmaceutical Federation (FIP), Amsterdam, The Netherlands, October 3 – 8, 2012.
  6. Maxwell, J; Lambert, R; Laudenbach, K; Adeyeye, M; Rasty, S; Adebayo, A; Ali, F; Potempa, L; MacKinnon, G. Highlights of Interprofessional Education at Roosevelt University College of Pharmacy (Poster), Annual AACP Meeting 14 – 18 July, 2012, Kissimmee, FL.
  7. Amusa S. Adebayo, Ravikiran Panakanti, Ruth Adewuya and Moji C. Adeyeye Improvement of PharmD Students Performance in a Biopharmaceutics and Pharmacokinetics Course Using Simulation Software, Annual AACP Meeting 14 – 18 July, 2012, Kissimmee, FL.
  8. Aderson-Foster, Naomi; Adebayo, S. Amusa and Justiz-Smith, Nilza. Emulsifying properties of Blighia sapida L. (Ackee) Oil; 2nd Conference in Innovation in Drug Delivery: From Formulation to Development through Innovative Evaluation Process, 3 -6 October, 2010, Aix-en-Provence, France pg. 163.
  9. Adebayo, S. A., Aderson-Foster, N. and Justiz-Smith, N. Extraction and Characterization of the Physico-chemical Properties of Blighia sapida (Ackee) Oil and its potential application as emulsion base; 2nd Conference in Innovation in Drug Delivery: From Formulation to Development through Innovative Evaluation Process, 3 – 6 October, 2010, Aix-en-Provence, France, pg. 215.
  10. Adebayo, A. S. Comparative Bioavailability and Bioequivalence of a novel Azithromycin capsule with a commercial preparation, 30th Annual Convention of the Caribbean Association of Pharmacists, 9 – 15 August, 2010, St. Lucia, West Indies.

            (b)          Publications

  1. Jankie Satish, Adebayo S. Amusa, Pillai Gopalakrishna (2012) In Vitro Activities of Fluoroquinolones Entrapped in Non-ionic Surfactant Vesicles against Ciprofloxacin-Resistant Bacteria Strains Journal of Pharmaceutical Technology & Drug Research http://www.hoajonline.com/journals/jptdr/content/pdf/5.pdf.
  2. Alexia C. Harvey, Amusa S. Adebayo , Andrew O. Wheatley, Helen N. Asemota , Cliff K. Riley (2012) Effects of Acetylation on the Micromeritics of Yam (Dioscorea sp.) Starch Powder for Pharmaceutical Application West African Journal of Pharmacy (2012) 23 (2) 40 – 50.
  3. Anderson, N, Adebayo, A. S, Smith, N. (2012) Physicochemical properties of Blighia sapida (Ackee) oil extract and its potential application as emulsion base, Afr. J. Pharm. and Pharmacol. 6(3): 200-210 (http://www.academicjournals.org/AJPP DOI: 10.5897/AJPP11.696).
  4. Riley C.K. and Sarafadeen A. Adebayo (2010) A comparative investigation of the packing and flow properties of sweet potato (Ipomoea batatas) starches and their potential use in solid dosage formulations Starch – Stärke, 62: 285–293. http://onlinelibrary.wiley.com/doi/10.1002/star.200900201/abstract.

Current Research

  1. Design and evaluation of chronopharmaceutics drug delivery system
  2. In-situ gelling ophthalmic delivery of drug for catarct
  3. Age-appropriate dosage forms of antiretroviral drugs

Grants Received

a.  NIH-Bridge summer students research on four different projects (May – August, 2012) ($1300/project/student):

  1. Ravikiran Panakanti, Moji Adeyeye, Amusa Adebayo and Ruth Adewuya - Development of Antiretroviral formulations for treating children with AIDS.
  2. Amusa Adebayo, Moji Adeyeye, Ravi Panakanti and Ruth Adewuya - Development of Oral Disintegrating Tablets of Antiretroviral Drugs.
  3. Moji Adeyeye, Amusa Adebayo, Ravi Panakanti and Ruth Adewuya - Characterization of In-Situ Gelling Polymer-Preservative Interaction in Ophthalmic Delivery Systems.
  4. Moji Adeyeye, Amusa Adebayo, Ravi Panakanti and Ruth Adewuya - Design and Evaluation of Dosage Form for the Circadian Rhythmic Delivery of Drugs.
    • Gastroplus from Simulations Plus, Inc, CA. $62,525.00 to date (A.S. Adebayo & M.C. Adeyeye) – ongoing teaching & research software support.
    • Phoenix WinNonlin from Pharsight Corporation (A Certara Company), CA. $112,496 to date (A. Adebayo & M. Adeyeye) - ongoing teaching & research software support.
    • Development of solid dosage form (Roquette America) $5000.00 (M. Adeyeye A. Adebayo & R. Panakanti) – active/ongoing.
  1. Teaching/Research Grant-in-Aid since joining Roosevelt University

Grant Proposal Submitted

  1. A.S. Adebayo & M.C. Adeyeye, Assay Development, Stability and Beyond-Use Dating of Compounded Gabapentin/Ketamine/Ketoprofen Combination Product in Organogel Base; International Academy of Compounding Pharmacists – Grant Program 2013: ($10,000.00; submitted April 2013).

Ruth Adewuya, MD
Affiliate Assistant Professor of Pharmaceutics
Pharmaceutics Laboratory Manager

 

 Research Specialization Summary

Women’s health; new and innovative teaching methods; application of technology in compounding laboratories; health education and promotion.

Scholarship (2010-)

            (a)  All abstracts submitted/accepted or presented

  1. AACP Annual Meeting, Chicago, IL. July 2013. Pharmacy Career Awareness of High School Students Post-Roosevelt University College of Pharmacy Career Trek Session, Ruth O Adewuya, Moji Adeyeye, Amusa Adebayo and Ravikiran Panakanti.
  2. National Institute of Health Bridges Student Research Presentation Roosevelt University, June 2012, Effect of Polymer Blend on the Characteristics of Ion-Activated In-Situ Gel Ophthalmic Delivery System for Use in the Treatment of Cataracts, Juan Vargas, Pierre-Louis Destruel, Rory Stewart, Shazia Sarwar, Amusa S Adebayo, Ravikiran Panakanti, Ruth Adewuya and Moji C Adeyeye.
  3. AACP Annual Meeting, Kissimmee, FL. July 2012, Improvement of PharmD students’ performance in a Biopharmaceutics and Pharmacokinetics Course using simulation software, Amusa S. Adebayo, Ravikiran Panakanti, Ruth Adewuya and Moji C. Adeyeye.
  4. AAPS 26th Annual Meeting, Chicago, IL, October 14-18, 2012, Age-appropriate Pharmacokinetic Prediction for Fixed Dose Combination (FDC) of Lamivudine, Nevirapine and Zidovudine using Adult Data obtained in a Phase 1 Clinical Trial.  Amusa S. Adebayo, Anjali Joshi, Fred Esseku, Ravi Panakanti, Ruth Adewuya and Moji C. Adeyeye.
  5. AAPS 26th Annual Meeting, Chicago, IL, October 14-18, 2012, Simulated Ocular Bioavailability of Estradiol Based on Preclinical Data in Rabbits. Amusa S. Adebayo, Uday Kotreka, Ravi Panakanti, Ruth Adewuya and Moji C. Adeyeye.

            (b)  Publications

  1. Book Chapter:  Mechanism of Drug Action in Head & Neck Cancer: Current Perspectives, Advances and Challenges.  S Kurup, KE Dineley, LM Malaiyandi and R Adewuya.  Editor: J. A. Radosevich. In Press.

Grants Received

  1. Moji Adeyeye, Ravi Panakanti and Amusa Adebayo and Ruth Adewuya, Undergraduate Honors Research Opportunity Program Grant, Characterization of In-Situ Gelling Polymer-Preservative Interaction in Ophthalmic Delivery Systems. 2011/2012. Funded two students. $1650.00.
  2. R. Adewuya, M. Aruru, F. Ali, T. Dymon, and M. Hogan, NACDS Foundation Million Hearts Team Up, Pressure Down Campaign Grants. Roosevelt University. 2012. Funded. $1000.00.

Moji Christianah Adeyeye, PhD
Professor of Pharmaceutics
Chair, Department of Biopharmaceutical Sciences

 

 Research Specialization Summary

  1. Preformulation, solid, liquid, ophthalmic and parenteral dosage forms development.
  2. Drug product development for pediatric critical disease states such as HIV/AIDS and tuberculosis. Bioavailability, bioequivalence, and in-vivo drug disposition simulation. Investigational and new drug application, and clinical trials

Scholarship (2010 -)

            (a)  Selected Presentations

  1. Providing Care and Developing Drug Products for HIV/AIDS Children: The Journey, Board of Trustees, Roosevelt University, March 17, 2011.
  2. Nigeria-Based Clinical Trial of Fixed Dose Combination Antiretroviral Drugs Intended for Pediatrics. Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria, May 31, 2011.
  3. From Bench to Bedside: Pharmaceutical Development in Academia, Moji Adeyeye, Biological and Chemical Engineering Sciences Department, Illinois Institute of Technology. Invited Presentation, October 12, 2011.
  4. Kotreka, U. K., Davis, V. L. and Adeyeye, Moji C., In vitro and In vivo Characterization of In situ Gel-Forming Estradiol Eye Drops. AAPS 25th Annual Meeting, Washington DC, October 23-27, 2011.
  5. Bioequivalence Clinical Trial of a Fixed-Dose Combination Antiretroviral Reconstitutable Suspension in Healthy Volunteers, Fredrick Esseku, Anjali Joshi, Yemisi Oyegbile, Grace Edohwhoru2, Daniel Gbadero, and Moji Adeyeye. AAPS 25th Annual Meeting, Washington DC, October 23-27, 2011.
  6. Bioequivalence Assessment of Zidovudine/Lamivudine/Nevirapine Fixed-Dose Combination Fast-Disintegrating Tablet: An Open-Label, Randomized, Two-Way Cross-Over Study in Healthy Volunteers. A. Joshi, F. Esseku, D. Gbadero, F. Adesanya, and M. Adeyeye.  AAPS 25th Annual Meeting, Washington DC, October 23-27, 2011.
  7. Amusa S. Adebayo, Ravikiran Panakanti, Ruth Adewuya and Moji C. Adeyeye, (2012) Improvement of PharmD students’ performance in a Biopharmaceutics and Pharmacokinetics Course using simulation software, AACP Annual Meeting, Kissimmee, FL.
  8. Juan Vargas, Pierre-Louis Destruel, Rory Stewart, Shazia Sarwar, Amusa S Adebayo, Ravikiran Panakanti, Moji C Adeyeye (2012) Effect of Polymer Blend on the Characteristics of Ion-Activated In-Situ Gel Ophthalmic Delivery System for Use in the Treatment of Cataracts, NIH Bridges, RUCOP.
  9. Velia Palma, Shirinbanu Patel, Janet Picaso, Ravikiran Panakanti, Amusa Adebayo and Moji Adeyeye (2012) Development of Age-Appropriate Anti-Retroviral Drug Formulations Intended for Prevention- of-Mother-to-Child-Transmission (PMTCT) of HIV/AIDS, NIH Bridges, RUCOP.
  10. Betty Villagomez, Janette Picaso, Cheryl Raju, Velia Palma, Amusa Adebayo, Ravikiran Panakanti and Moji Adeyeye (2012) Design and Evaluation of Dosage Form for the Circadian Rhythmic Delivery of Asthma Therapy, NIH Bridges, RUCOP.

            (b)  Publications

  1. Fredrick Esseku, Mark Lesher, Vishal Bijlani, Samantha Lai, Ewart Cole and Moji Adeyeye,  The Effect of Overencapsulation on Disintegration and Dissolution  Pharmaceutical Technology Volume 34, Issue 4, pp. 104-111, 2010.
  2. A. Joshi, F. Esseku, L. Silva, C. Igwilo, D. Oqua, B. Kunle, O. Obodozie, U. Inyang and Moji C. Adeyeye, Post-marketing In-vitro/in-vivo Assessment of Fixed Dose Combination Products of First Line Antiretrovirals. J. Pharm. Sci, 99(6):2655-63, 2010.
  3. Udaya K. Kotreka and Moji Christianah Adeyeye. Gastro-Retentive Floating Drug Delivery Systems: A Critical Review.  Critical Reviews in Therapeutic Drug Carrier Systems, 28(1), 47-99, 2011.
  4. Fredrick Esseku and Moji Christianah Adeyeye. Bacteria and pH-sensitive polysaccharide-polymer films for colon targeted delivery. Crit Rev Ther Drug Carrier Syst 2011; 28(5):395-445.
  5. Frederick Esseku, Anjali Joshi and Moji Christianah Adeyeye, Paediatric HIV/AIDS Drug Formulation Development In Academic Institutions As A Cost Reduction Strategy. International Pharmacy Pharmaceutical Federation Journal, Vol 27, No. 3 December 2011.
  6.  Anjali Joshi and Moji Christianah Adeyeye, Reversed Phase LC-UV Method Development and Validation for Simultaneous Determination of Three Antiretroviral: Lamivudine, Zidovudine, Nevirapine and Possible Degradants in a Fixed Dose Pharmaceutical Product.  Pharmaceutical Technology & Drug Research 2012 1: 4 (24 April 2012). http://www.hoajonline.com/jptdr/1/1/4.
  7. Fredrick Esseku, Anjali Josh, Yemisi Oyegbile, Grace Edowhorhu, Daniel Gbadero, and Moji Adeyeye, A Randomized Phase I Bioequivalence Clinical Trial of a Pediatric Fixed-Dose Combination Antiretroviral Reconstitutable Suspension in Healthy Adult Volunteers. Antiviral Therapy. 2012.  doi: 10.3851/IMP2310. In Press
    http://www.intmedpress.com/journals/avt/abstract.cfm?id=2310&pid=48.

 Current Research

  1. Solid and liquid-state characterization of drug substances and excipients. 
  2. Bench-to-Bedside translational research on pediatric antiretroviral solid dosage forms including development of dosage forms and filing for investigational new drug application. Development and optimization of polymer-based in-situ gelling ophthalmic delivery system.

Grants Received

  1. Moji Adeyeye, Ravikiran Panakanti and Amusa Adebayo and Ruth Adewuya, Undergraduate Honors Research Opportunity Program Grant, Characterization of In-Situ Gelling Polymer-Preservative Interaction in Ophthalmic Delivery Systems. 2011/2012. Funded two students: $1650.00.
  2. Moji Adeyeye, Ravikiran Panakanti and Amusa Adebayo. Development of Selected Immediate Release Tablets. Funded: $5000. Roquette Corporation.
  3. Ravikiran Panakanti, Amusa Adebayo, and Moji Adeyeye, Characterization of Different Solid Dosage Foorms and an Ophthalmic Delivery SystemFunded: $3750.00. NIH Bridges to Baccalaureate Program. 

Grants-in-aid

  1. Moji Adeyeye and Amusa Adebayo: Pharsight Phoenix WinNonlin Pharmacokinetic Teaching License Simulation Software Donation. Funded:  $92,510.00.
  2. Moji Adeyeye and Amusa Adebayo Simulation Plus: GastroPlus Pharmacokinetic/Pharmacodynamic Teaching License Simulation Software Donation: Moji Adeyeye and Amusa Adebayo: Funded: $52,394.
  3. Moji Adeyeye, Sonali Kurup and Ravikiran Panakanti: Research Equipment donated by Fitzpatrick Co. and Dr. Norman Frankel respectively. Funded: $110,000 and $72,205.00.

Paiboon Jungsuwadee, PhD
Assistant Professor of Pharmacology

 

 Research Specialization Summary

My research focus is to investigate the physiological role of multidrug-resistance associated protein (MRP) 1 efflux transporter protein as well as MRP1 regulation. Specifically, I am interested in examining the roles for MRP1 that could lead to an identification of a novel target for specific disorders such as Alzheimer’s disease, asthma, and glaucoma.

Scholarship (2010-)

            (a)  Publications

  1. Paiboon Jungsuwadee, Michael R. Weaver, Fabienne Gally and Rebecca E. Oberley-Deegan. The Metalloporphyrin Antioxidant, MnTE-2-PyP, Inhibits Th2 Cell Immune Responses in an Asthma Model. Int. J. Mol. Sci. 2012, 13:9785.
  2. Paiboon Jungsuwadee, Tianyong Zhao, Elzbieta Stolarczyk, Christian M. Paumi, D. Allan Butterfield, Daret K. St Clair, and Mary Vore. A single nucleotide polymorphism (SNP) of MRP1 (G671V) decreases GS-HNE transport. Pharmacogenetics and Genomics 2012; 22(4):273-84.
  3. Bakthavatchalu V., Dey D., Xu Y., Noel T., Jungsuwadee P., Holley A., Dhar S.K., Batinic-Haberle I., and St. Clair D.K. Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Pol against UV-induced inactivation. Oncogene 31(17):2129.
  4. Aluise CD, Miriyala S, Noel T, Sultana R, Jungsuwadee P, Taylor TJ, Cai J, Pierce WM, Vore M, Moscow JA, St Clair DK, Butterfield DA. 2-Mercaptoethanesulfonate (MESNA) prevents doxorubicin(Dox)-induced plasma protein oxidation and TNF release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain. FRBM, 2011. 50(11):1630-8.
  5. Velez JM, Miriyala S, Nithipongvanitch R, Noel T, Plabplueng CD, Oberley T, Jungsuwadee P, Van Remmen H, Vore M, St Clair DK. p53 regulates oxidative stress-mediated retrograde signaling: A novel mechanism for chemotherapy-induced cardiac injury. PLos One, 2011. 30;6(3):e18005.
  6. Antony Athippozhy, Liping Huang, Tianyong Zhao, Clavia Ruth Wooton-Kee, Paiboon Jungsuwadee, Arnold J. Stromberg, and Mary Vore. Utilizing a Mixed Model Approach to Compare the Lactating Rat Transcriptome Against Age-Matched Control Virgins. BMC Genomics, 2011. 12(1):95.
  7. Tangpong J, Miriyala S, Noel T, Sinthupibulyakit C, Jungsuwadee P, St Clair DK. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia Mangostana. Neuroscience, 2011. 175:292-9.
  8. Megaraj V, Iida T, Jungsuwadee P, Hofmann AF, and Vore M. Hepatobiliary disposition of 3α,6α,7α,12α-tetrahydroxy-cholanoyl taurine: A substrate for multiple canalicular transporters. Drug Metabolism and Disposition, 2010. 38(10):1723-30.

Current Research

  1. To study gene expression of H2O2-induced oxidative stress in human trabecular meshwork cells (In collaboration with Dr. Kelly Wintz-Hunter).

Grants Received

  1. July 1, 2011, Husson University, School of Pharmacy.
    Inhibition of Multidrug-resistance associated protein-2 (MRP2) in Amiodarone-treated HepG2 exacerbates cell death. Amount awarded $6,618.

Grant Proposal Submitted

  1. August 28, 2012, 2012-2013 New Investigator Award Application
    Two-step treatment modality for Sezary syndrome. Amount requested $9,999.32.
  2. March 31, 2011, Maine cancer foundation
    Oxidative stress-induced MRP1 expression via Nrf2-HDM2-p53 pathway in HepG2 cells. Amount requested $89,334.00.

Sonali Kurup, PhD
Assistant Professor of Medicinal Chemistry

 

 Research Specialization Summary

  1. Design, Synthesis and Evaluation of Multi-targeted HIV Inhibitors
    Small molecules with designed multi-target inhibitory attributes could alleviate the concerns of existing HIV therapies. A single scaffold could be optimally substituted to incorporate an overlapping set of key recognition elements for binding to two or more target enzymes. Target compounds have been designed for HIV reverse transcriptase and HIV integrase. Research methods include structure-based drug design, synthesis and biochemical evaluation of the target compounds.
  2. Fragment Based Screening Approaches for the Identification of Novel Enzyme Inhibitors
    Innovative drug discovery methods are required to expand and accelerate the discovery process. Fragment-based screening provides a novel approach for non-peptidic inhibitor identification. Research methods include virtual screening of a fragment library, followed by synthesis and biochemical evaluation of the compounds against target proteases and kinases.

Scholarship (2010-)

            (a)  All abstracts submitted/accepted or presented

  1. “Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors.” Gangjee, A.; Kurup, S.; Smith, C.D.  Bioorg. Med. Chem. 2013, 21, 1180-9.
  2. N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.” Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Disch, B.  Bioorg. Med. Chem. 2012, 20, 910-14.
  3. “Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular    endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.” Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Shenoy, S.  Bioorg. Med. Chem. 2010, 18, 3575-87.

            (b)  Presentations

  1. “Using Molecular Modeling to Integrate Biochemistry and Medicinal Chemistry in a Pharmacy Curriculum” Kurup, S.; Potempa, L. A. Poster presentation at the American Association of the Colleges of Pharmacy (AACP) Annual Meeting, Kissimmee, FL, July 14-18, 2012.
  2. “A Team-Based Unknown Drug Project Linking Medicinal Chemistry, Pharmacology and Clinical Pharmacy”, Fuentes, D.G.; Benken, S.T.; Kurup, S. Poster presentation at the American Association of the Colleges of Pharmacy (AACP) Annual Meeting, Kissimmee, FL, July 14-18, 2012.

Grants Received

  1. Summer Faculty Grant ($1500); 2011; Office of the Provost, Roosevelt University, Schaumburg, IL.
  2. NIH Bridges Program ($2000); 201; Elgin Community College-Roosevelt University.
    Kimax New Lab Start-up Program ($1000); 2012.

Paul L. Ornstein, PhD
Associate Professor of Medicinal Chemistry

 

 Research Specialization Summary

I am an accomplished medicinal chemist in the neuroscience area, having delivered 8 clinical candidates for neurological and psychiatric disorders. My work at Lilly has resulted in 52 issued US patents. I have published 108 papers and given 48 invited lectures on my scientific work. I have also had an active involvement in the international scientific community, as the Chair of the 1998 Heterocyclic Compounds GRC, and as the organizer of many scientific sessions at US and European meetings 

Scholarship (2010-)

            (a)  Publications

  1. Adventures in Drug Discovery, A Retrospective: iGluR5 kainate receptor antagonists as novel treatments for migraine and pain.  Presented at the Paquette Legacy Symposium, The Ohio State University, Columbus, Ohio, May 14, 2011.
  2. Adventures in Drug Discovery: A Brief Retrospective.  Presented at the Saul Winstein 100th Birthday Symposium, University of California, Los Angeles, October 6. 2012.
  3. Adventures in Drug Discovery: Perspective and Retrospective, to be presented at Gilead Pharmaceuticals, July 12, 2013.
  4. Schober, D.A.; Gill, M.B.; Yu, H.; Gernert, D.L.; Jeffries, M.W.; Ornstein, P.L.; Kato, A.S.; Felder, C.C.; Bredt, D.S.  Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. J. Biol. Chem., 2011, 286, 13134-13142.

My research will focus on the optimization of structure activity relationships toward treatments that target novel mechanisms.  The hope is to decrease the treatment burden while also providing more effective drugs for TB.

Grant in kind

  1. Your Encore to support research collaboration with the Lilly TB Drug Discovery Initiative Planning Grant for the NIH Building Infrastructure Leading to Diversity (BUILD) Initiative (P20), NIH.

Ravikiran Panakanti, PhD
Assistant Professor Pharmaceutics

 

 Research Specialization Summary

Gene therapy is an approach that uses genes to treat or prevent disease either by over expressing a functional gene/protein that has been inhibited or by knocking out or silencing the expression of an aberrant gene/protein. Gene therapy in spite of being a promising option for treating number of diseases including cancer and certain chronic metabolic disorders still has some concerns related to immunogenicity. We would like to develop novel gene delivery systems by using the combination of drug delivery systems that are safe and efficacious.

 

Scholarship (2010-)

            (a)   All abstracts submitted/accepted or presented

  1. Ravikiran Panakanti, Amusa Adebayo, Ruth Adewuya and Moji Adeyeye  (2013) Implementation of fresh pedagogical tools - group exams, in class quizzes and integrative approach to enhance student learning of pharmaceutics in a 3 year accelerated pharmd program, AACP Annual Meeting, Chicago, IL 
  2. Velia Palma, Shirinbanu Patel, Janet Picaso, Ravikiran Panakanti, Amusa Adebayo and Moji Adeyeye (2012) Development of Age-Appropriate Fast-Dispersible Pediatric Anti-Retroviral Drug Formulations Intended for the Prevention of Mother-to-Child Transmission of HIV/AIDS, Annual Biomedical Research Conference for Minority Students (ABRCMS), San Jose, CA.  Received Best Poster award.
  3. Amusa S Adebayo, Uday Kotreka, Ravi Panakanti, Ruth Adewuya and Moji C Adeyeye, (2012) Simulated Ocular bioavailability of Estradiol based on preclinical data in rabbits, AAPS Annual Meeting, Chicago, IL.
  4. Amusa S Adebayo, Anjali Joshi, Fred Esseku, Ravi Panakanti, Ruth Adewuya and Moji C Adeyeye, (2012) Age appropriated Pharmacokinetic prediction for fixed dose combination (FDC) of lamivudine, nevirapine and Zidovudine using adult data obtained in phase 1 clinical trial, AAPS Annual Meeting, Chicago, IL.
  5. Amusa S. Adebayo, Ravikiran Panakanti, Ruth Adewuya and Moji C. Adeyeye, (2012) Improvement of PharmD students’ performance in a Biopharmaceutics and Pharmacokinetics Course using simulation software, AACP Annual Meeting, Kissimmee, FL.
  6. Yang N, Panakanti R and Mahato RI (2011) Treatment of Liver Fibrosis by M6P-HPMA-TFO. 15th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT.

    (b)  Publications

  1. Pratap A, Singh S, Mundra V, Yang N, Panakanti R, Eason JD, Mahato RI. Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling. J Drug Target. 2012 Nov:20(9):770-82.
  2. Panakanti R, Narang AS. Impact of excipient interactions on drug bioavailability from solid dosage forms. Pharm Res. 2012 Oct: 29(10):2639-59.
  3. Pratap A, Panakanti R, Yang N, Lakshmi R, Modanlou KA, Eason JD, Mahato RI. Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: hope for marginal livers. Mol Pharm. 2011 Jun 6:8(3):958-68.
  4. Panakanti R, Pratap A, Yang N, Jackson JS, Mahato RI. Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation. Biochem Pharmacol. 2010 Dec 1:80(11):1718-26.
  5. Pratap A, Panakanti R, Yang N, Eason JD, Mahato RI. Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion. Pharm Res. 2010 Nov:27(11):2492-504.
  6. Panakanti R and Mahato RI (2009) Recent advances in gene expression and delivery systems. In: Narang AS and Mahato RI (eds) Targeted Delivery of Small and Macromolecular Drugs, CRC Press, Inc.

Current Research

  1. Development of rapidly dissolving pharmaceutical formulations that will be easier to administer to children that can greatly reduce the incidence of mother to child transmission of HIV.
  2. Development of ophthalmic drug delivery systems to prolong the contact time of the formulation on the ocular surface, which depends on rheological and mucoadhesive properties of the ophthalmic formulations.

Grants Received

NIH-Bridge summer students’ research

  1. Development of antiretroviral formulations for treating children with AIDS; Funding Amount: $ 1250.00.
  2. Modeling & Simulation of ADME of Pediatric HIV/AIDS Patients on Powder for Reconstitution & Fast Disintegrating Tablets; Funding Amount: $ 1250.00.
  3. Characterization of In-Situ Gelling Polymer-Preservative Interaction in Ophthalmic Delivery Systems; Funding Amount: $ 1250.00.
  4. Design and Evaluation of Dosage Form for the Circadian Rhythmic Delivery of Drugs; Funding Amount: $ 1250.00.
  5. Roosevelt University Undergraduate Research Opportunity Program (Fall 2011)- Development of antiretroviral formulations for treating children with AIDS.

Grant Proposal Submitted

  1. AACP-New Investigator Award (2012): “Combinatorial Therapy of Diabetes Mellitus using Betacellulin and GLP-1” Amount: $10,000.00.

Lawrence Potempa, PhD
Associate Professor Biochemistry and Immunology

 

 Research Specialization Summary

Innate immunity and inflammation; specifically, evaluation of structure/function relationships of C-reactive protein as a biological response modifier. The focus is on potent pro-inflammatory molecule termed modified, monomeric CRP  (mCRP)

Scholarship (2010 -)

            (a)          All abstracts submitted/accepted or presented

  1. Ji S-R, Wang M-Y, Bai C-J, Potempa LA, Filep JG,  Wu Y. 2012. Sequential conformation changes in C-reactive protein are required to activate endothelial cells.  European Atherosclerosis Society Congres (EAS); Milan, Italy on May 25-28, 2012.
  2. Kurup S, Potempa LA. 2012.  Using Molecular Modeling to Integrate Biochemistry and Medicinal Chemistry in a Pharmacy Curriculum.  Amer Asso College of Pharmacy Annual Meeting.
  3. Chauhan BC, Potempa LA, Davis FJ, Chauhan NB. 2013. Natural Expression of C-reactive protein and its isoforms in a mouse model of Alzheimer’s disease.  Am Assoc College Pharmacy annual meeting.

            (b)         Publications

  1.  Wang M-Y, Ji S-R, Bai C-J, El Kebir D, Li H-Y, Shi J-M, Zhu W, Costantino S, Zhou H-H, Potempa LA, Zhao J, Filep JG,  Wu Y. 2011.  A redox switch in C-reactive protein modulates activation of endothelial cells.  FASEB J. 25:3186-3196
  2. 3.  El Kebir D, Zhang Y, Wang L, Potempa LA, Wu Y, Fournier A, Filep JG. 2011. C-reactive protein-derived peptide 201-206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32.  Journal of Leukocyte Biology 90(6):1167-1175.
  3. 4. Boras E, Slevin M, Alexander MY, Gilmore W, Ashworth J, Krupinski J, Potempa LA, Abuulkareem IA, Matou-Nasri S. 2013.  Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signaling pathway.  Submitted to Cytokine. June 2013.
  4. Boncler M, Rywaniak J, Szymanski J, Potempa LA, Rychlik B, Watala C. 2011. Modified C-reactive protein interacts with platelet glycoprotein Iba. Pharmacological Reports 63:464-475.

Grants Received

      1.    ELISA  plate  reader,  Plate  washer,  and  Plate  shaker  ApDia  –  of  Belgium

Grant Proposal Submitted

  1. Collaborator/coinvestigator on an NIH grant submitted by:  Professor Alok Agrawol, PhD, Department of Pharmacology, East Tennessee State University Johnson City, TN 37614.

 

Department of Clinical and Administrative Sciences

Fatima Ali, PharmD
Assistant Professor, Clinical Sciences

    (a)    All abstracts submitted/accepted or presented

  1. Avalos P, Ali F.  Review of aerosolized antimicrobials for the treatment of hospital-acquired and ventilator-associated pneumonia.  American College of Clinical Pharmacy:  Albuquerque, New Mexico, October 2013 (accepted).
  2. Ali, F, Brock, C.  Over the Counter Aisle as Method for Student Assessment in Pharmaceutical Care Lab.  American Association of  Colleges of Pharmacy:  Chicago, IL, July 2013.
  3. Ali F, Aruru, M, Brock, C, et al.  Resident Teaching Certificate Program at Roosevelt University College of Pharmacy.  American Society of Health-System Pharamacists Midyear Clinical Meeting:  Las Vegas, NV, December 2012.
  4. New Practioners Forum (Committee Member).  New Practitioners Forum Poster.  American Society of Health-System Pharamacists Midyear Clinical Meeting, Student Society Showcase:  Las Vegas, NV, December 2012.
  5. Ali, F, Wieczorkiewicz, S, Cwik, J.  Procalcitonin-Guided Duration of Antimicrobial Therapy for the Treatment of Lower Respiratory Tract Infections.  Illinois Council Health-System Pharmacist Annual Meeting, Oak Brook, IL.  September 2011.
  6. Ali, F, Wieczorkiewicz, S, Cwik, J.  Procalcitonin Guided Duration of Antimicrobial Therapy for Patients with Healthcare Associated Pneumonia.  Advocate Research Forum, Park Ridge, IL.  May 2011.

    (b)   Publications

  1. Ali, F, Wieczorkiewicz, S, Cwik, J.  Procalcitonin-Guided Duration of Antimicrobial Therapy for the Treatment of Lower Respiratory Tract Infections. KeePosted.  2011, Nov.  
  2. Nagel, K, Ali, F, Al-Khudari, S,et al.  Extemporaneous Compounding of Medicated Ointment.  International Journal of Pharmaceutical Compounding.  2010; 14(6):472-8.

     (c)    Presentations

  1. Nonprescription Therapeutics Poster Symposium.  American Association of Colleges of Pharmacy Annual Meeting:  Chicago, IL, July 2013.  (Presented via Video Learning Lounge).
  2. Developing Professionalism amongst First-Year Pharmacy Students.  Roosevelt University Mini-Conference on Teaching:  Chicago, IL, April 2013.  (Presented to faculty from other colleges on campus).                

Current Research

  1. Review of aerosolized antimicrobials for the treatment of hospital-acquired and ventilator-associated pneumonia.
  2. Procalcitonin Guided Duration of Antimicrobial Therapy for Patients with Healthcare Associated Pneumonia.

 Grants Received

  1. September 2012, National Association of Chain Drug Stores Community Fair 2012 collaborative grant (funded)       

Grant Proposal Submitted

  1. May 2013, American Society of Health-System Pharmacists Student Society Development Grant (not funded).

 

Meghana Aruru, PhD
Assistant Professor, Administrative Sciences

    
    (a)    All abstracts submitted/accepted or presented 

  1. Dineley K, Aruru MV. “Utilizing Group-Based Exams as an assessment modality in PharmD Education”. School Poster. American Association of Colleges of Pharmacy, Chicago, IL, 2013
  2. Linton L, Aruru MV. ‘Readability of patient education materials across Rheumatoid Arthritis and Multiple Sclerosis Disease States’. American Pharmacists Association, Los Angeles, CA, April 2013
  3. Ngo L, Aruru MV. ‘Hepatitis B outbreaks in assisted living facilities’. American Pharmacists Association, Los Angeles, CA, April 2013
  4. Ali F, Aruru MV, Brock C, et. al.  ‘Resident Teaching Certificate Program at Roosevelt University College of Pharmacy’.  American Society of Health-System Pharmacists Midyear Clinical Meeting, Las Vegas, NV, December 2012.
  5. Brock C, Aruru MV, MacKinnon K, Fuentes D. ‘Combining “Top 150” drug knowledge with adherence by assigning a simulated 10-week single-drug regimen. ‘ American Association of Colleges of Pharmacy, Kissimmee, FL, July 2012.

    (b)  Presentations  

  1. Aruru MV, Brock C. “Combining Management and MTM: Utilizing MTM business plans as a student-learning tool”. Roundtable discussion. American Association of Colleges of Pharmacy, Chicago, IL, 2013.
  2. Aruru MV.  Albert Schweitzer Fellowships. Special Session on “Public Health Opportunities for PharmD students”. American Association of Colleges of Pharmacy, Chicago, IL, 2013.
  3. Aruru MV, Salmon B, Salmon J.W. ‘Pharmaceuticals and Environmental Sustainability: A time for change?’ American Public Health Association, Boston, MA, 2013 (upcoming).
  4. Aruru MV, Hogan M. ‘Analysis of Online Veterinary Pharmacy regulations in the United States’. American Public Health Association, Boston, MA, 2013 (upcoming).
  5. Douglas GW, Aruru MV, Salmon JW, Cordes L, Walsh S. ‘Developing an Effective Inventory Management System for a NGO Medical Mission’. American Public Health Association, Boston, MA, 2013 (upcoming).
  6. Aruru MV, Salmon JW. Analysis of Indoor Tanning Regulations in the United States, Canada, Europe, Australia and New Zealand. American Public Health Association, San Francisco, CA, November 2012.
  7. Hogan M, Aruru MV. ‘Does pet owner knowledge about zoonotic infections lead to improved adherence for preventive medications for dogs?’ American Public Health Association, Boston, MA, 2013 (Upcoming).

Cara Brock, PharmD
Clinical Instructor, Clinical Sciences
Co-Director Pharmaceutical Care Labs

     
    (a)    All abstracts submitted/accepted or presented

  1. Brock CM, Fuentes DG, Aruru MV, MacKinnon K. Combining Top 150 Drug Knowledge with Adherence by Assigning a Simulated 10-week Single Drug Regimen. Poster presentation; American Association of Colleges of Pharmacy Annual Meeting; Kissimmee, FL,2012.
  2.  Brock, CM. Norwegian American Hospital Patient Safety and Clinical Pharmacy Collaborative Team. Poster presentation; Health Resources and Administration Patient Safety Clinical Pharmacy Services Collaborative Session at the American Pharmacists’ Association Annual Meeting; New Orleans, LA, 2012.

    (b)   Presentations

  1. Ali F, Aruru M, Brock CM, et al. Resident Teaching Certificate Program at Roosevelt University College of Pharmacy. American Society of Health-System Pharmacists Midyear Clinical Meeting; Las Vegas NV, 2012.
  2. Brock CM. Using a Passport to Test Skills in the Clinical Lab. Roundtable presentation; American Association of Colleges of Pharmacy Annual meeting; Kissimmee, FL, 2012.

Tara Dymon, PharmD
Assistant Professor, Clinical Sciences

    (a)    Presentations

  1. Fuentes D, Dymon T, Rasty S. Clinical Considerations and controversies for anticoagulations in geriatric patients- session 113-L01, ACPE 204-000-12-113- L01P ( 2 ACPE approved CPE credit hr).

Abby Kahaleh, PhD
Associate Professor, Pharmacy Education

    
    (a)    All abstracts submitted/accepted or presented

  1. Nathan Fowler, Leakena Sou, Dora Holeman, Kelly Lee, Lauren Nach,, Kahaleh AA. Pharmacist-led counseling to improve transition of care. American Health-System Pharmacists Midyear Clinical meeting. (Submitted) December 2013.
  2. Nathan Fowler, Leakena Sou, Dora Holeman, Kelly Lee, Lauren Nach, Kahaleh AA. Pharmacists’ role to participate in high-performing interprofessional teams to improve patient care. American Health-System Pharmacists Midyear Clinical meeting. (Submitted) December 2013.
  3. Christian Dang, Hawibiya Uma, Samuel Wilberforce, Samuel Alemie. Kahaleh AA. The role of pharmacists in interprofessional teams to reduce medication errors and provide patient-centered healthcare. American Health-System Pharmacists Midyear Clinical meeting. (Submitted) December 2013.
  4. Anderson K, Ohrlund J, Caddigan N, Kennedy S, Kahaleh AA. Recognizing pharmacists as healthcare providers. (Submitted). Illinois Pharmacists Association Annual Meeting. September, 2013. 
  5.  Ohrlund J, Kennedy S, Anderson K, Caddigan N, Kahaleh AA. Leadership and advocacy opportunities for the RUCOP student pharmacists. April, 2013. (Submitted). Illinois Pharmacists Association Annual Meeting. September, 2013. 
  6. Kahaleh AA. Continuous Quality Improvement in Experiential Education Assessment. American Pharmacists Association Annual Meeting. Los Angeles, CA. March 2013.

    (b)   Presentations

  1. Kahaleh AA. Danielson J, Nuffer W, Franson K, Truong H, Umland E. Innovative Interprofessional Education and Collaborative Practice Models. American Association of Colleges of Pharmacy. Chicago, Illinois. July 2013. 
  2. Kahaleh AA. Health Behavior Theories and Models: Frameworks, Implementation Strategies, and Motivational Interviewing. North Suburban Pharmacists. Northbrook, IL. March 2012.
  3. Harmonizing Clinical Competencies: Can We all Sing the Same Tune Yet? Ried D, Archer J, Kahaleh AA. American Association of Colleges of Pharmacy Annual Meeting. Kissimmee, FL. July 2012.
  4. Kahaleh AA. Brown K, Tuner C, Franson K, Nuffer W. Longitudinal Assessment of Learning Outcomes in Experiential Education. American Association of Colleges of Pharmacy. San Antonio, TX. July 2011.

    (c)    Publications 

  1. Kahaleh AA. Applying Health Belief Models to Improve Patient Care Services in Community Settings. IPhA on-line CE Articles. http://www.ipha.org/ce/ces.php. 2011.  
  2. Kahaleh AA. Health Care Delivery: A Primer for Pharmacists. Student Guide. In Robert L. McCarthy and Kenneth W. Shafermeyer. Fifth Edition. Jones and Bartlett Publisher. 2011.
  3. Kahaleh AA. Pharmacy Management, Leadership, Marketing, and Finance. Student Guide. In Chisholm-Burns, Vaillancourt, and Shepherd. Jones and Bartlett Publisher. 2011.

Matthew Nelson, PharmD
Assistant Professor, Clinical Sciences

    (a)    Publications 

  1. Nelson, Matthew. "Implementation of the Pharmacy Practice Model Initiative: a Resident Perspective." KeePosted Vol 8 Issue 6 July 2012.

Prashant Sakharkar, PharmD
Associate Professor, Administrative Sciences

    (a)    Presentations

  1. Cost Effectiveness Analysis of Lueprolide versus Goserelin in the Treatment of Metastatic Prostate Cancer in the Bahamas, ISPOR 2013, May 2013, New Orleans (Abstract)
  2. Cost Effectiveness Analysis of Medical Management of Incomplete Miscarriages in the Bahamas, ISPOR 2013, May 2013, New Orleans (Abstract)
  3. Effect of the new functional CYP3A4 intron 6, CYP3A5 and ABCB1 polymorphisms on the Tacrolimus concentrations in Hispanic kidney transplant recipients, American Transplant Congress, Seattle, WA, May 2013 (Abstract)
  4. Polymorphism of the Vitamin D Receptor and Risk of New-Onset Diabetes after Transplantation in Hispanic Kidney Transplant Recipients, American Transplant Congress, Seattle, WA, May 2013 (Abstract)
  5. Association of Interferon-γ gene polymorphisms with cytomegalovirus viremia in renal allograft recipients, American Transplant Congress, Seattle, WA, May 2013 (Podium)
  6. Type and Extent of Unused Medications: A Survey at Community Pharmacy Drugs Take Back Events, APhA Annual Meeting & Exposition, Los Angeles, CA, March 2013 (Podium)
  7. Examining Effectiveness of Educational Interventions to Improve Prescription Label Comprehension and its Correlation with STOFHLA: A Pilot Study, APhA Annual Meeting & Exposition, Los Angeles, CA, March 2013 (Poster)
  8. Medication Adherence to Lipid Lowering Drugs in Hyperlipidemia: The Extent and Outcomes, APhA Annual Meeting & Exposition, Los Angeles, CA, March 2013 (Poster)
  9. Adherence with Immunosuppressant Therapy and allograft outcomes in Hispanic Kidney Transplant Recipients, APhA Annual Meeting & Exposition, Los Angeles, CA, March 2013 (Poster)
  10. Impact of Cytokine Gene Polymorphism on BK Virus Nephropathy in a Large Cohort of Kidney Transplant Recipients, ACCP Annual Meeting, Hollywood, FL, Oct 2012 (Podium - Best Paper among Great 8 session)
  11. Association of Interferon gamma gene polymorphisms with BK virus nephropathy in renal allograft recipients, ACCP Annual Meeting, Hollywood, FL, Oct 2012
  12. Cost-minimization analysis of Aripiprazole versus Lithium for the treatment of pediatric Bipolar I Disorder (BPD I) in the United States, ASHP Mid Year Meeting & Exhibition, Las Vegas, NV, Dec. 2012 (Poster)
  13. Angiotensin Receptor Blockers and risk of Cardiovascular Death in patient with Type 2 Diabetes Mellitus, ISPOR 2012, June 2012, Washington DC (Abstract)
  14. Validation of PSPSQ Measuring Patient Satisfaction with Psychiatric Pharmacy Services, ISPOR 2012, June 2012, Washington DC (Abstract)
  15. Attitudes and Behaviors of Patients and Pharmacists towards Complementary and Alternative Medicine Products, APhA 2012 Annual Meeting & Exposition, New Orleans, 2012 (Abstract)
  16. Health care provider and patient attitudes, behaviors, and practices regarding Complementary and Alternative Medicine (CAM) products, Western StatesConference for Residents, May 2012, Pacific Groove, CA (Abstract)
  17. Impact of Pharmacist in Achieving Therapy Goals, Medication Adherence, and Patient Satisfaction in patients with psychiatric illnesses in an Outpatient Setting, College of Psychiatric and Neurologic Pharmacist Conference, April 2012, Tampa, FL (Abstract)
  18.   Validity and Reliability of Instruments used for measuring Patient Satisfaction with Pharmaceutical Care Services, APhA 2012 Annual Meeting & Exposition, New Orleans, 2012 (Abstract)
  19. Development and Validation of PSPSQ measuring Patient Satisfaction with Pharmacist Clinical Services, APhA 2012 Annual Meeting & Exposition, New Orleans, 2012 (Abstract)
  20. Validity and Reliability of Instruments used for measuring Patient Satisfaction with Pharmaceutical Care Services, ISPOR Latin America Conference, Mexico, Sept. 2011 (Abstract)
  21. Examining Prescription Medication Wastage in US Households: A Validation Study, APhA 2011 Annual Meeting and Exposition, Seattle, WA, March, 2011 

Publications

  1. Vu D, Sakharkar P, Shah T, Naraghi R, Yasir Q, Hutchinson I, Min D. Association of Interferon gamma gene polymorphisms with BK virus infection among Hispanic renal allograft recipients. Transplantation, 2013 (In press)
  2. Vu Don, Sakharkar Prashant, Tellez-Corrales Eglis, Shah Tariq, Hutchinson Ian, Min David. Taq I Polymorphism of the Vitamin D Receptor and Risk of New-Onset Diabetes after Transplantation in Hispanic Kidney Transplant Recipients. Molecular Biology report, 2013 (In press)
  3. Schwartzman Emmanuelle, Chung Eunice, Sakharkar Prashant, Law Anandi V. Instruction and assessment of student communication skills in US and Canadian pharmacy curricula. Currents in Pharmacy Teaching & Learning, 2013 (In press)
  4.  Vu D, Tellez-Corrales E, Sakharkar P, Kissen MS, Shah T, Hutchinson I, Min DI. Impact of NF-κB gene polymorphism on allograft outcome in Hispanic renal transplant recipients, Transplant Immunology, Transpl Immunol. 2012 Nov 12. doi:pii: S0966-3274(12)00107-4. 0.1016/j.trim.2012.11.001. [Epub ahead of print] PMID: 23153769
  5. Vu D, Sakharkar P. Tellez-Corrales E, Shah T, Hutchinson I, Min D. Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients.  Mol Biol Rep, 2012, Oct 17. [Epub ahead of print] PubMed PMID: 23070913
  6. Sakharkar P, Phung O, Law AV. How Do Health Outcomes and Pharmacoeconomics Impact “Real-World” Pharmacy Practice?  California Pharmacist. Vol. LVIII (2), Spring 2011, 20-25.

Current Research

  1. Assessing and improving Functional Health Literacy (FHL) and Prescription Label Comprehension using the LaRue tools and educational intervention
  2. Assessing effects of response shift on HRQOL measurement among cancer patients on active treatment
  3. Improving Functional Health Literacy and Prescription Label Comprehension among elderly population
  4. Assessing the Impact of Cultural Competency course among Pharmacy Students of Roosevelt University College of Pharmacy on their Attitudes & Behavior   

Grants Submission

  1. NIH/R21 PA-11-163, 2011 Pharmacists’ Cultural Competence and Perception of Care by Ethnic Minorities Total Estimated Project Funding: $330,401
  2. NIH/R21 PA-11-135, 2011 Improving Functional Health Literacy and Prescription Label Comprehension Total Estimated Project Funding: $ 421,642
  3. AACP New Investigator Award, 2011 Angiotensin Receptor Blockers and Cardiovascular Disease in Type II Diabetes Mellitus Total Estimated Project Funding: $7,262

Sharon Sam, PharmD
Assistant Professor, Clinical Sciences

    (a)    All abstracts submitted/accepted or presented

  1. Sam S, Clark J, Greenberg A, Sincak C, Shaikh Z, Dominguez E. Relationship Between Varying Daptomycin MICs and Outcomes in Enterococcal Bacteremia; Poster presentation; Infectious Diseases Society of America Conference; San Diego, CA; October 2012.
  2. Sam S. Implementation of an Antimicrobial Stewardship Program: the Who, What, and Why?; Poster presentation; Methodist Health System Quality Summit; Dallas, TX; September 2010.
  3. Sam S, Vais D, Crank C, Segreti J, Lin M. Risk Factors for Treatment Failure in Prosthetic Joint Infections; Poster presentation; Infectious Diseases Society of America Conference; Philadelphia, PA; October 2009.
  4. Sam S, Fink J, Mawhorter S. Seroconversion Rates with an Accelerated Hepatitis A and/or B Vaccine Schedule in Heart Transplant Candidates; Poster presentation; American College of Clinical Pharmacy Conference; Louisville, KY; October 2008.

    (b)   Publications

  1. Olansky L, Sam S, Lober C, Yared JP, Hoogwerf B. J Diabetes Sci Technol. Cleveland Clinic Cardiovascular Intensive Care Unit Insulin Conversion Protocol. 2009;3(3):478-486.
  2. Sam, S. Antimicrobial Stewardship: Optimizing Antimicrobial Therapy. KeePosted. 35(3);March 2009.
  3. Sam, S. Prevention of Infective Endocarditis: 2007 Guidelines from the American Heart Association (AHA). Pharmacotherapy Update. 2008 Mar/Apr; 11(2):1-4.
  4. Sam, S. Getting Ahead in Pursuit of a Pharmacy Practice Residency. KeePosted. Jan 2007.

    (c)    Current Research

  1. Comparing clinical and microbiological outcomes of ceftriaxone to the standard of care (first generation cephalosporin or anti-staphylococcal penicillins) for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia.
  2. Comparing clinical outcomes between oral vancomycin capsules and oral vancomycin suspension which is compounded from intravenous vancomycin for the treatment of severe Clostridium difficile infection.
  3. Evaluating the clinical success of using high-dose tigecycline for the treatment of multi-drug resistant gram negative urinary tract infections.
  4. Evaluating reductions in prescribing and dosing errors when micafugin is therapeutically interchanged for caspofungin.